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M9630037.TXT
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1996-02-27
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Document 0037
DOCN M9630037
TI [The presence of HIV DNA in the neutrophils of persons infected with the
human immunodeficiency virus and the clinical parallels of this
phenomenon]
DT 9603
AU Gabrilovich DI; Vasilev VB; Nosikov VV; Serebrovskaia LV; Shepeleva GK;
Ivanova LA; Pokrovskii VV
SO Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct;(5):52-5. Unique
Identifier : AIDSLINE MED/96093392
AB Relationships between some clinical data and the detection of human
immunodeficiency virus (HIV) DNA in polymorphonuclear neutrophils (PMN)
of 37 HIV-infected persons were studied. HIV DNA was determined with the
use of polymerase chain reaction. The level of HIV DNA in PMN,
sufficient for determination, was mostly detected in persons with
clinical manifestations of HIV infection and less frequently in
asymptomatic patients (46.7% and 18.2% respectively, p < 0.05). The
significant relationship between the presence of HIV DNA in NP and a
decrease in the CD4/CD8 ratio, as well as an increase in the level of
immunoglobulins in the blood serum, has been established. The presence
of HIV DNA in PMN was positively related to the decrease of the
functional activity of these cells and the level of PMN in peripheral
blood. The infection of PMN with HIV may be one of important mechanisms
of their damage in HIV infection.
DE Adult Cell Separation Comparative Study CD4-CD8 Ratio DNA,
Viral/*BLOOD/ISOLATION & PURIF English Abstract Female Human HIV
Infections/*BLOOD/VIROLOGY HIV-1/*GENETICS Male Neutrophils/*VIROLOGY
Nitroblue Tetrazolium/DIAGNOSTIC USE Phagocytosis Polymerase Chain
Reaction/METHODS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).